Discovery of FtsZ inhibitors by virtual screening as antibacterial agents and study of the inhibition mechanism-Reference-Cited by-同舟云学术

Discovery of FtsZ inhibitors by virtual screening as antibacterial agents and study of the inhibition mechanism

Published:2022 Issue:1 Volume:13 Page:79-89
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Du Ruo-Lan¹,Sun Ning¹^ORCID,Fung Yik-Hong¹,Zheng Yuan-Yuan¹,Chen Yu-Wei¹^ORCID,Chan Pak-Ho¹,Wong Wing-Leung¹^ORCID,Wong Kwok-Yin¹^ORCID

Affiliation:

1. State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hunghom, Kowloon, Hong Kong, P.R. China

Abstract

S2727 (Dacomitinib) was virtually screened out from a compound library via targeting the PC 190723 binding site of FtsZ and its inhibition effect on the functions of FtsZ was demonstrated by biological assays.

Funder

Ministry of Science and Technology of the People's Republic of China

Innovation and Technology Commission

Hong Kong Polytechnic University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D1MD00249J

Reference48 articles.

1. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem