Total synthesis of (–)-deglycocadambine-Reference-Cited by-同舟云学术

Total synthesis of (–)-deglycocadambine

Published:2024 Issue:17 Volume:11 Page:4869-4873
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Wang Fang-Xin¹^ORCID,Chen Ying-Tao¹,Liu Hui¹,Wang Heng-Shan¹^ORCID,Liang Hong¹^ORCID,Chen Zhen-Feng¹^ORCID,Chi Yonggui Robin²³^ORCID

Affiliation:

1. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources/Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China

2. School of Chemistry, Chemical Engineering, and Biotechnology, Nanyang Technological University, Singapore 637371, Singapore

3. National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025, China

Abstract

The first total synthesis of (–)-deglycocadambine is achieved from (+)-genipin, wherein the well-designed cascade annulation and the late-stage transannular oxidative cyclization clearly unveil the bond-forming logic in this synthetic route.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangxi Zhuang Autonomous Region

National Research Foundation Singapore

Ministry of Education - Singapore

Nanyang Technological University

Guizhou Science and Technology Department

Guangxi Normal University

Project 211

Guizhou University

Department of Education of Guizhou Province

Publisher