Ligand-based pharmacophore modeling, virtual screening and biological evaluation to identify novel TGR5 agonists-Reference-Cited by-同舟云学术

Ligand-based pharmacophore modeling, virtual screening and biological evaluation to identify novel TGR5 agonists

Published:2021 Issue:16 Volume:11 Page:9403-9409
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhao Shizhen¹²³⁴⁵^ORCID,Li Xinping¹²³⁴⁵,Peng Wenjing¹²³⁴⁵,Wang Le¹²³⁴⁵,Ye Wenling¹²³⁴⁵,Zhao Yang¹²³⁴⁵,Yin Wenbo⁶⁷⁸⁹¹⁰,Chen Wei-Dong¹²³⁴⁵,Li Weiguo¹²³⁴⁵,Wang Yan-Dong¹¹¹²¹³¹⁴⁵

Affiliation:

1. Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery

2. People's Hospital of Hebi

3. School of Medicine

4. Henan University

5. China

6. Key Laboratory of Structure-Based Drug Design and Discovery

7. Ministry of Education

8. School of Pharmaceutical Engineering

9. Shenyang Pharmaceutical University

10. Shenyang 110016

11. State Key Laboratory of Chemical Resource Engineering

12. College of Life Science and Technology

13. Beijing University of Chemical Technology

14. Beijing

Abstract

The ligand-based virtual screening combined with pharmacophore mapping and molecular docking was performed to identify novel nonsteroidal TGR5 agonists.

Funder

National Natural Science Foundation of China

Henan Provincial Natural Science Foundation

Fundamental Research Funds for the Central Universities

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D0RA10168K

Reference33 articles.