Enhanced penetrative siRNA delivery by a nanodiamond drug delivery platform against hepatocellular carcinoma 3D models-Reference-Cited by-同舟云学术

Enhanced penetrative siRNA delivery by a nanodiamond drug delivery platform against hepatocellular carcinoma 3D models

Published:2021 Issue:38 Volume:13 Page:16131-16145
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Xu Jingru¹²,Gu Mengjie¹²,Hooi Lissa²,Toh Tan Boon³,Thng Dexter Kai Hao²,Lim Jhin Jieh²,Chow Edward Kai-Hua¹²³⁴⁵^ORCID

Affiliation:

1. Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore

2. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore

3. The N.1 Institute for Health, National University of Singapore, 117456, Singapore

4. Department of Biomedical Engineering, National University of Singapore, 117583, Singapore

5. NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University Singapore, Singapore

Abstract

Comprehensive analysis of hepatocellular carcinoma 3D models revealed enhanced penetrative siRNA delivery by a nanodiamonds compared to liposomes. Nanodiamonds were able to improve siRNA's gene knockdown and anti-cancer effects in 3D tumor models.

Funder

Ministry of Education - Singapore

National Research Foundation Singapore

National Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NR/D1NR03502A

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