Novel huperzine A based NMDA antagonists: insights from molecular docking, ADME/T and molecular dynamics simulation studies-Reference-Cited by-同舟云学术

Novel huperzine A based NMDA antagonists: insights from molecular docking, ADME/T and molecular dynamics simulation studies

Published:2020 Issue:43 Volume:10 Page:25446-25455
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Sigalapalli Dilep Kumar¹²³⁴,Rangaswamy Raghu⁵⁶⁷⁴,Tangellamudi Neelima D.¹²³⁴^ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. National Institute of Pharmaceutical Education and Research (NIPER)

3. Hyderabad 500037

4. India

5. Department of Bioinformatics

6. Alagappa University

7. Karaikudi – 630 003

Abstract

The in silico study explores the structural behavior and binding affinities of 40 novel analogues of huperzine A. Novel NMDA receptor antagonists have been virtually identified by molecular docking, ADME/T and molecular dynamics simulation studies.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA00722F

Reference34 articles.

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5. Natural Oligomers of the Alzheimer Amyloid- Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

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