Model biomolecular condensates have heterogeneous structure quantitatively dependent on the interaction profile of their constituent macromolecules-Reference-Cited by-同舟云学术

Model biomolecular condensates have heterogeneous structure quantitatively dependent on the interaction profile of their constituent macromolecules

Published:2022 Issue:35 Volume:18 Page:6674-6693
ISSN:1744-683X
Container-title:Soft Matter
language:en
Short-container-title:Soft Matter

Author:

Shillcock Julian C.¹^ORCID,Lagisquet Clément²^ORCID,Alexandre Jérémy³,Vuillon Laurent²^ORCID,Ipsen John H.⁴^ORCID

Affiliation:

1. Blue Brain Project and Laboratory of Molecular and Chemical Biology of Neurodegeneration, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland

2. LAMA, Univ. Savoie Mont Blanc, CNRS, LAMA, 73376 Le Bourget du Lac, France

3. Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland

4. Dept. of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark

Abstract

Model biomolecular condensates have heterogeneous material properties that are tuned by the number and distribution of their constituent proteins’ sticky binding sites.

Funder

École Polytechnique Fédérale de Lausanne

Centre National de la Recherche Scientifique

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SM/D2SM00387B

Reference139 articles.

1. Liquid–liquid phase separation: a principal organizer of the cell’s biochemical activity architecture

2. Functional Implications of Intracellular Phase Transitions