Development of double strand RNA mPEI nanoparticles and application in treating invasive breast cancer-Reference-Cited by-同舟云学术

Development of double strand RNA mPEI nanoparticles and application in treating invasive breast cancer

Published:2019 Issue:23 Volume:9 Page:13186-13200
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Liu Rui¹²³⁴⁵,Mu Li-Min¹²³⁴⁵,Bai Jing¹²³⁴⁵,Du Ya-Fei¹²³⁴⁵,Xie Ying¹²³⁴⁵,Lu Wan-Liang¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Natural and Biomimetic Drugs

2. Beijing Key Laboratory of Molecular Pharmaceutics and New Drug System

3. School of Pharmaceutical Sciences

4. Peking University

5. Beijing 100191

Abstract

dsRNA mPEI nanoparticles entered cytoplasm and lysosomal escape occurred. dsRNA was released to form a dsRNA–RISC complex. Then, remaining sense strand bound to mRNA, forming a new structure. Thus, mRNA was cleared and translation was inhibited.

Funder

Natural Science Foundation of Beijing Municipality

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA01889A

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