Bioreducible polymer-mediated delivery of oncolytic adenovirus can attenuate antiviral immune response and concurrently enhance the induction of antitumor immune response to effectively prevent metastasis

Author:

Kasala Dayananda1,Lee Soo-Hwan1,Hong JinWoo2,Oh Eonju1,Yoon A-Rum134,Yun Chae-Ok1234ORCID

Affiliation:

1. Department of Bioengineering, College of Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea

2. GeneMedicine Co., Ltd, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea

3. Institute of Nano Science and Technology (INST), Hanyang University, Seoul, Republic of Korea

4. Hanyang Institute of Bioscience and Biotechnology (HY-IBB), Hanyang University, Seoul, Republic of Korea

Abstract

Bioreducible polymer modified oAd can overcome CAR-dependent entry and lead to enhance expression of therapeutic genes, viral replication, and infiltration of T cells into the tumor tissues, ultimately resulting in improved therapeutic index of oAd.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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