Bioreducible polymer-mediated delivery of oncolytic adenovirus can attenuate antiviral immune response and concurrently enhance the induction of antitumor immune response to effectively prevent metastasis-Reference-Cited by-同舟云学术

Bioreducible polymer-mediated delivery of oncolytic adenovirus can attenuate antiviral immune response and concurrently enhance the induction of antitumor immune response to effectively prevent metastasis

Published:2022 Issue:15 Volume:10 Page:4293-4308
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Kasala Dayananda¹,Lee Soo-Hwan¹,Hong JinWoo²,Oh Eonju¹,Yoon A-Rum¹³⁴,Yun Chae-Ok¹²³⁴^ORCID

Affiliation:

1. Department of Bioengineering, College of Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea

2. GeneMedicine Co., Ltd, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea

3. Institute of Nano Science and Technology (INST), Hanyang University, Seoul, Republic of Korea

4. Hanyang Institute of Bioscience and Biotechnology (HY-IBB), Hanyang University, Seoul, Republic of Korea

Abstract

Bioreducible polymer modified oAd can overcome CAR-dependent entry and lead to enhance expression of therapeutic genes, viral replication, and infiltration of T cells into the tumor tissues, ultimately resulting in improved therapeutic index of oAd.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D2BM00200K

Reference57 articles.

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