Cisplatin and oleanolic acid Co-loaded pH-sensitive CaCO3 nanoparticles for synergistic chemotherapy

Author:

Khan Muhammad Waseem1ORCID,Zou Chenming2,Hassan Said3,Din Fakhar Ud4ORCID,Abdoul Razak Mahaman Yacoubou5,Nawaz Asif6,Alam Zeb 7,Wahab Abdul8,Bangash Sudhair Abbas9

Affiliation:

1. Institute of Pharmaceutical Sciences, Khyber Medical University, Peshawar, Pakistan

2. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

3. Institute of Biotechnology and Microbiology, Bacha Khan University, Charsadda, Pakistan

4. Department of Pharmacy, Quaid-I-Azam University, Islamabad 45320, Pakistan

5. Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

6. Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Pakistan

7. Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan

8. Department of Pharmacy, Kohat University of Science and Technology, Kohat, Pakistan

9. Faculty of Life Science, Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan

Abstract

Despite being one of the most potent anticancer agents, cisplatin (CDDP) clinical usage is limited owing to the acquired resistance and severe adverse effects including nephrotoxicity.

Funder

Higher Education Commission, Pakistan

National Natural Science Foundation of China

Huazhong University of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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