Understanding how cAMP-dependent protein kinase can catalyze phosphoryl transfer in the presence of Ca2+and Sr2+: a QM/MM study-Reference-Cited by-同舟云学术

Understanding how cAMP-dependent protein kinase can catalyze phosphoryl transfer in the presence of Ca2+and Sr2+: a QM/MM study

Published:2017 Issue:16 Volume:19 Page:10377-10394
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Pérez-Gallegos Ayax¹²³,Garcia-Viloca Mireia¹²³,González-Lafont Àngels¹²³^ORCID,Lluch José M.¹²³^ORCID

Affiliation:

1. Institut de Biotecnologia i de Biomedicina and Departament de Química, Universitat Autònoma de Barcelona

2. 08193 Bellaterra (Barcelona)

3. Spain

Abstract

Theoretical results demonstrate for the first time at the molecular level that the overall PKAc-catalyzed phosphoryl-transfer reaction is plausible with Ca²⁺and Sr²⁺, alkaline earth metal ions other than Mg²⁺, which is in good agreement with experiments.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CP/C7CP00666G

Reference93 articles.

1. The phosphorylase b to a converting enzyme of rabbit skeletal muscle

2. The role of protein phosphorylation in human health and disease.

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4. Novel protein kinases and molecular mechanisms of autoinhibition

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