Ph3P-mediated highly selective C(α)–P coupling of quinone monoacetals with R2P(O)H: convenient and practical synthesis of ortho-phosphinyl phenols

Author:

Shen Ruwei12345ORCID,Zhang Ming12345,Xiao Jing678,Dong Chao12345,Han Li-Biao678ORCID

Affiliation:

1. State Key Laboratory of Materials-Oriented Chemical Engineering

2. College of Chemical Engineering

3. Nanjing Tech University

4. Nanjing 210009

5. China

6. National Institute of Advanced Industrial Science & Technology (AIST)

7. Tsukuba

8. Japan

Abstract

The Ph3P-mediated C(α)–P coupling reaction of quinone monoacetals with secondary phosphine oxides is developed to provide an effective method for the synthesis of a wide array of ortho-phosphinyl phenols in good to excellent yields.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Nanjing Tech University

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Reference74 articles.

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3. The clinical potential of the acyclic (and cyclic) nucleoside phosphonates. The magic of the phosphonate bond

4. Synthesis of Nucleoside Phosphate and Phosphonate Prodrugs

5. Surface Modification Using Phosphonic Acids and Esters

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