Efficient synthesis and preliminary biological evaluations of trifluoromethylated imidazo[1,2-a]pyrimidines and benzimidazo[1,2-a]pyrimidines-Reference-Cited by-同舟云学术

Efficient synthesis and preliminary biological evaluations of trifluoromethylated imidazo[1,2-a]pyrimidines and benzimidazo[1,2-a]pyrimidines

Published:2019 Issue:25 Volume:43 Page:9961-9968
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Jismy Badr¹²³⁴⁵,Akssira Mohamed⁶⁷⁸⁹¹⁰,Knez Damijan¹¹¹²¹³¹⁴,Guillaumet Gérald¹⁵¹⁶¹⁷¹⁸¹⁹,Gobec Stanislav¹¹¹²¹³¹⁴,Abarbri Mohamed¹²³⁴⁵^ORCID

Affiliation:

1. Laboratoire de Physico-Chimie des Matériaux et des Electrolytes pour l’Energie (PCM2E)

2. EA 6299

3. Avenue Monge Faculté des Sciences

4. Parc de Grandmont

5. 37200 Tours

6. Laboratoire de Chimie Physique & de Chimie Bioorganique

7. URAC 22

8. Université Hassan II de Casablanca

9. 28800 Mohammedia

10. Morocco

11. University of Ljubljana

12. Faculty of Pharmacy

13. 1000 Ljubljana

14. Slovenia

15. Institut de Chimie Organique et Analytique (ICOA)

16. Université d’Orléans

17. UMR CNRS 7311

18. 45067 Orléans Cedex 2

19. France

Abstract

Fluoromethylated imidazo[1,2-a]pyrimidines and benzimidazo[1,2-a]pyrimidines were synthesized through Michael addition/intramolecular cyclization reaction by condensation of 2-amino imidazole derivatives with ethyl 4,4,4-trifluorobut-2-ynate and using C–O bond activation.

Funder

Javna Agencija za Raziskovalno Dejavnost RS

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/NJ/C9NJ01982K

Reference66 articles.

1. Research on heterocyclic compounds. XXXII. Synthesis and cyclooxygenase-independent antiinflammatory and analgesic activity of imidazo[1,2-a]pyrimidine derivatives

2. Synthesis and biological evaluation of novel imidazopyrimidin-3-amines as anticancer agents

3. Synthesis and antibacterial activity of novel 5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine-2-carbohydrazide derivatives