Synthesis of novel 1,2,3-triazole based artemisinin derivatives and their antiproliferative activity

Author:

Kapkoti Deepak Singh1234,Singh Shilpi5234,Luqman Suaib5234,Bhakuni Rajendra Singh1234ORCID

Affiliation:

1. Medicinal Chemistry Department

2. CSIR-Central Institute of Medicinal and Aromatic Plants

3. Lucknow-226015

4. India

5. Molecular Bioprospection Department

Abstract

Novel artemisinin-1,2,3-triazole derivatives show significant antiproliferative activity, and induce apoptosis and ROS generation and arrest the cell cycle at the G2/M phase.

Funder

Council of Scientific and Industrial Research

Central Institute of Medicinal and Aromatic Plants

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Reference52 articles.

1. Qinghaosu (Artemisinin): an Antimalarial Drug from China

2. R. S. Bhakuni , D. C.Jain and R. P.Sharma , in Artemisia, Medicinal and Aromatic Plants Industrial Profiles , ed. C. Wright , Taylor & Frances , London , 2002 , pp. 211–248

3. Pharmacokinetic and Pharmacodynamic Profiles of Rapid-Acting Artemisinins in the Antimalarial Therapy

4. Cytotoxicity of Artemisinin-Related Endoperoxides to Ehrlich Ascites Tumor Cells

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