Synthesis of novel 1,2,3-triazole based artemisinin derivatives and their antiproliferative activity
Author:
Affiliation:
1. Medicinal Chemistry Department
2. CSIR-Central Institute of Medicinal and Aromatic Plants
3. Lucknow-226015
4. India
5. Molecular Bioprospection Department
Abstract
Novel artemisinin-1,2,3-triazole derivatives show significant antiproliferative activity, and induce apoptosis and ROS generation and arrest the cell cycle at the G2/M phase.
Funder
Council of Scientific and Industrial Research
Central Institute of Medicinal and Aromatic Plants
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,General Chemistry,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2018/NJ/C7NJ04271J
Reference52 articles.
1. Qinghaosu (Artemisinin): an Antimalarial Drug from China
2. R. S. Bhakuni , D. C.Jain and R. P.Sharma , in Artemisia, Medicinal and Aromatic Plants Industrial Profiles , ed. C. Wright , Taylor & Frances , London , 2002 , pp. 211–248
3. Pharmacokinetic and Pharmacodynamic Profiles of Rapid-Acting Artemisinins in the Antimalarial Therapy
4. Cytotoxicity of Artemisinin-Related Endoperoxides to Ehrlich Ascites Tumor Cells
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