Cationic peroxidase from proso millet induces human colon cancer cell necroptosis by regulating autocrine TNF-α and RIPK3 demethylation

Author:

Cui Xiaodong12345ORCID,Wang Ru12345,Wang Zhuanhua12645

Affiliation:

1. Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education

2. P.R. China

3. Institute of Biotechnology

4. Shanxi University

5. Taiyuan 030006

6. School of Life Science

Abstract

Two distinct mechanisms are involved in PmPOD-induced necroptosis, including the autocrine production of TNF-α and the restoration of RIPK3 expression in RIPK3-silenced cells.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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