Synthesis of 2-alkyl-2-boryl-substituted-tetrahydrofurans via copper(i)-catalysed borylative cyclization of aliphatic ketones-Reference-Cited by-同舟云学术

Synthesis of 2-alkyl-2-boryl-substituted-tetrahydrofurans via copper(i)-catalysed borylative cyclization of aliphatic ketones

Published:2019 Issue:23 Volume:17 Page:5680-5683
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kubota Koji¹²³⁴⁵^ORCID,Uesugi Minami⁵⁶²³⁴,Osaki Shun⁵⁶²³⁴,Ito Hajime¹²³⁴⁵^ORCID

Affiliation:

1. Institute for Chemical Reaction Design and Discovery (WPI-ICReDD)

2. Hokkaido University

3. Sapporo

4. Japan

5. Division of Applied Chemistry and Frontier Chemistry Center

6. Faculty of Engineering

Abstract

A new method was developed for synthesizing 2-alkyl-2-boryl-tetrahydrofuran derivatives from aliphatic ketones using a copper(i)/N-heterocyclic carbene complex catalyst.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB00962K

Reference30 articles.

1. Bis-Tetrahydrofuran: a Privileged Ligand for Darunavir and a New Generation of HIV Protease Inhibitors That Combat Drug Resistance

2. From Oxiranes to Oligomers: Architectures of U.S. FDA Approved Pharmaceuticals Containing Oxygen Heterocycles

3. Design and synthesis of potent HIV-1 protease inhibitors with ( S )-tetrahydrofuran-tertiary amine-acetamide as P2−ligand: Structure−activity studies and biological evaluation

4. Synthetic routes to tetrahydrofuran, tetrahydropyran, and spiroketal units of polyether antibiotics and a survey of spiroketals of other natural products

5. Activation of 6-endo over 5-exo hydroxy epoxide openings. Stereoselective and ring selective synthesis of tetrahydrofuran and tetrahydropyran systems

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