Process knowledge for drug substance production <i>via</i> kinetic modeling, parameter estimability analysis and reaction optimization-Reference-Cited by-同舟云学术

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Process knowledge for drug substance production via kinetic modeling, parameter estimability analysis and reaction optimization

Published:2024 Issue: Volume: Page:
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Moshiritabrizi Iman¹,McMullen Jonathan P.²^ORCID,Wyvratt Brian M.²^ORCID,McAuley Kimberley B.¹^ORCID

Affiliation:

1. Department of Chemical Engineering, Queen's University, Kingston, Ontario, K7L 3N6, Canada

2. Process Research & Development, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065, USA

Abstract

A mechanistic model that accounts for uncertain inputs is developed to study a key step in production of islatravir, an HIV drug.

Funder

Merck

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RE/D4RE00210E

Reference65 articles.

1. Development of a Commercial Manufacturing Route to 2-Fluoroadenine, The Key Unnatural Nucleobase of Islatravir

2. Case Studies in the Development of Drug Substance Control Strategies

3. S.Chatterjee , C. M.Moore and M. M.Nasr , An overview of the role of mathematical models in implementation of quality by design paradigm for drug development and manufacture, Comprehensive Quality by Design for Pharmaceutical Product Development and Manufacture , 2017 , vol. 1

4. Emerging Challenges and Opportunities in Pharmaceutical Manufacturing and Distribution

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