Enantioselective <i>de novo</i> synthesis of 14-hydroxy-6-oxomorphinans-Reference-Cited by-同舟云学术

Enantioselective de novo synthesis of 14-hydroxy-6-oxomorphinans

Published:2024 Issue:47 Volume:60 Page:6007-6010
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Moore Jonathan C.¹²^ORCID,Modell Louis³,Glenn Jacqueline R.⁴⁵,Jones Kieran D.¹²^ORCID,Argent Stephen P.²^ORCID,Lane J. Robert⁴⁵,Canals Meritxell⁴⁵,Lam Hon Wai¹²^ORCID

Affiliation:

1. The GlaxoSmithKline Carbon Neutral Laboratories for Sustainable Chemistry, University of Nottingham, Jubilee Campus, Triumph Road, Nottingham, NG7 2TU, UK

2. School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK

3. School of Pharmacy, University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, UK

4. Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK

5. Centre of Membrane Protein and Receptors, Universities of Birmingham and Nottingham, The Midlands, UK

Abstract

The enantioselective de novo synthesis of pharmacologically important 14-hydroxy-6-oxomorphinans is described. 4,5-Desoxynaltrexone and 4,5-desoxynaloxone were prepared using this route and their biological activities against the opioid receptors were measured.

Funder

Leverhulme Trust

Biotechnology and Biological Sciences Research Council

Academy of Medical Sciences

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC01788A

Reference57 articles.

1. DARK Classics in Chemical Neuroscience: Morphine

2. The DARK Side of Total Synthesis: Strategies and Tactics in Psychoactive Drug Production

3. Chemical Interventions for the Opioid Crisis: Key Advances and Remaining Challenges

4. World Health Organisation (WHO). “WHO Model List of Essential Medicines – 23rd list, 2023’’ (Publication WHO/MHP/HPS/EML/2023.02, WHO, 2023 ; https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2023.02 )

5. The chemical and pharmacological importance of morphine analogues