Enhanced selectivity towards melanoma cells with zinc(ii)-Schiff bases containing imidazole derivatives

Author:

Côrte-Real Leonor1ORCID,Sergi Baris2ORCID,Yildirim Busra2ORCID,Colucas Raquel1,Starosta Radosław13ORCID,Fontrodona Xavier4,Romero Isabel4ORCID,André Vânia1ORCID,Acilan Ceyda52ORCID,Correia Isabel1ORCID

Affiliation:

1. Centro de Química Estrutural, Institute of Molecular Sciences, and Department of Chemical Engineering, Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais 1, 1049-001 Lisboa, Portugal

2. Koç University, Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey

3. Faculty of Chemistry, University of Wrocław, ul. F. Joliot-Curie 14, 50-383 Wrocław, Poland

4. Departament de Química and Serveis Técnicas de Recerca, Universitat de Girona, Spain

5. Koç University, School of Medicine, Sariyer, Istanbul, Turkey

Abstract

New Schiff base Zn(ii)-complexes of 8-hydroxyquinoline and imidazole display much higher selectivity towards cancer cells than cisplatin.

Funder

Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi

Universitat de Girona

Generalitat de Catalunya

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

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