Synthesis of N-acyl amide natural products using a versatile adenylating biocatalyst-Reference-Cited by-同舟云学术

Synthesis of N-acyl amide natural products using a versatile adenylating biocatalyst

Published:2019 Issue:7 Volume:10 Page:1192-1196
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Marchetti Piera M.¹²³⁴^ORCID,Richardson Shona M.¹²³⁴^ORCID,Kariem Noor M.¹²³⁴^ORCID,Campopiano Dominic J.¹²³⁴^ORCID

Affiliation:

1. EastCHEM School of Chemistry

2. University of Edinburgh

3. Edinburgh

4. UK

Abstract

TamA is the enzyme that controls the acyl chain length of the tambjamine natural products. Here we show that the catalytic ANL domain of TamA can be used to prepare a range of N-acyl amides.

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

University of Edinburgh

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00063A

Reference31 articles.

1. A New Golden Age of Natural Products Drug Discovery

2. Natural Products as Sources of New Drugs from 1981 to 2014

3. Natural products: A continuing source of novel drug leads

4. The re-emergence of natural products for drug discovery in the genomics era

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