Alteration of steric hindrance modulates glutathione resistance and cytotoxicity of three structurally related RuII-p-cymene complexes-Reference-Cited by-同舟云学术

Alteration of steric hindrance modulates glutathione resistance and cytotoxicity of three structurally related RuII-p-cymene complexes

Published:2016 Issue:20 Volume:45 Page:8541-8555
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Purkait Kallol¹²³⁴,Chatterjee Saptarshi¹²³⁴,Karmakar Subhendu¹²³⁴,Mukherjee Arindam¹²³⁴

Affiliation:

1. Department of Chemical Sciences

2. Indian Institute of Science Education and Research Kolkata

3. Mohanpur Campus

4. India

Abstract

Three structurally related Ru^II-p-cymene complexes of imidazole based Schiff bases show steric hindrance influences, hypoxia reactivity, cell cycle arrest and resistance to glutathione. The complexes show anti-metastatic and anti-angiogenic effects.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/DT/C5DT04781A

Reference77 articles.

1. Exploring biologically relevant chemical space with metal complexes

2. Bioorganometallic chemistry—from teaching paradigms to medicinal applications

3. Areneruthenium complexes as anticancer agents