A novel procedure for the synthesis of borylated quinolines and its application in the development of potential boron-based homeodomain interacting protein kinase 2 (HIPK2) inhibitors-Reference-Cited by-同舟云学术

A novel procedure for the synthesis of borylated quinolines and its application in the development of potential boron-based homeodomain interacting protein kinase 2 (HIPK2) inhibitors

Published:2022 Issue:37 Volume:12 Page:24187-24191
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Das Bhaskar C.¹²^ORCID,Yadav Pratik¹^ORCID,Das Sasmita¹,He John Cijiang²³

Affiliation:

1. Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA

2. Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

3. Renal Section, James J. Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA

Abstract

This report reveals a Pd catalyzed C-4 borylation of structurally complex chloroquinolines with B2(pin)2 without the use of any external ligand for the synthesis of potential boron-based homeodomain interacting protein kinase 2 inhibitors.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA05063C

Reference24 articles.

1. How cells switch HIPK2 on and off

2. Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation

3. Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis