Affiliation:
1. School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan
Abstract
The stereo-controlled total synthesis of (−)-domoic acid is described, including the crucial formation of the trisubstitutedZ-olefin moiety and the incorporation of the side chain using modified Julia–Kocieński reaction in the final stage.
Funder
Japan Agency for Medical Research and Development
Ministry of Education, Culture, Sports, Science and Technology
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry