An antifouling supramolecular polymer ophthalmic ointment alleviates symblepharon in rat alkali burn eyes-Reference-Cited by-同舟云学术

An antifouling supramolecular polymer ophthalmic ointment alleviates symblepharon in rat alkali burn eyes

Published:2024 Issue:15 Volume:12 Page:3905-3917
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Liang Minghui¹²,Wang Zhuoya³,He Kai²,Liao Mengyu²,Zhang Haokun²,Guo Miao²,Liang Shuqi¹²,Guo Haixia²,Xie Songbo²,Wang Xiaohong²⁴,Du Mei²⁴,You Caiyun²,Yang Jianhai³^ORCID,Yan Hua¹²^ORCID

Affiliation:

1. School of Medicine, Nankai University, Tianjin, 300071, China

2. Department of Ophthalmology, Tianjin Medical University General Hospital, Ministry of Education International Joint Laboratory of Ocular Diseases, Tianjin Key Laboratory of Ocular Trauma, Tianjin Institute of Eye Health and Eye Diseases, China-UK “Belt and Road” Ophthalmology Joint Laboratory, Tianjin, 300052, China

3. School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300350, China

4. Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, 300070, Tianjin, China

Abstract

An antifouling supramolecular polymer PNAVL ophthalmic ointment, consisting of poly (N-acryloyl alaninamide) (PNAAA), vitamin C (VitC) and levofloxacin (Levo), could mitigate symblepharon after rat ocular alkali burn injury.

Funder

National Basic Research Program of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/BM/D4BM00637B

Reference27 articles.

1. An update on chemical eye burns

2. A rabbit model for assessing symblepharon after alkali burn of the superior conjunctival sac

3. Fibrosis and diseases of the eye

4. Current and Upcoming Therapies for Ocular Surface Chemical Injuries

5. Methoxyeugenol deactivates hepatic stellate cells and attenuates liver fibrosis and inflammation through a PPAR-ɣ and NF-kB mechanism