Total synthesis of biselide A-Reference-Cited by-同舟云学术

Total synthesis of biselide A

Published:2021 Issue:15 Volume:12 Page:5534-5543
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Challa Venugopal Rao¹²³⁴,Kwon Daniel¹²³⁴,Taron Matthew¹²³⁴,Fan Hope¹²³⁴,Kang Baldip¹²³⁴,Wilson Darryl¹²³⁴,Haeckl F. P. Jake¹²³⁴^ORCID,Keerthisinghe Sandra¹²³⁴,Linington Roger G.¹²³⁴^ORCID,Britton Robert¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Simon Fraser University

3. Burnaby

4. Canada

Abstract

A total synthesis of the marine macrolide biselide A is described that relies on an enantiomerically enriched α-chloroaldehyde as the sole chiral building block.

Funder

Natural Sciences and Engineering Research Council of Canada

Michael Smith Foundation for Health Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC06223E

Reference83 articles.

1. Marine cytotoxic macrolides haterumalides and biselides, and related natural products

2. Haterumalide B: A new cytotoxic macrolide from an Okinawan ascidian Lissoclinum sp.