Curcumin affords protection against valproic acid induced teratogenicity by curtailing oxidative stress and inhibiting CYP2C9 activity-Reference-Cited by-同舟云学术

Curcumin affords protection against valproic acid induced teratogenicity by curtailing oxidative stress and inhibiting CYP2C9 activity

Published:2015 Issue:101 Volume:5 Page:82756-82764
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Kumar Akhilesh¹²³⁴⁵,Chandasana Hardik⁶²³⁴⁵,Bhatta Rabi Sankar⁶²³⁴,Sethi Nikunj¹²³⁴⁵,Yadav Sudhaker¹²³⁴,Sinha Neeraj¹²³⁴⁵

Affiliation:

1. Division of Toxicology

2. CSIR-Central Drug Research Institute

3. Lucknow 226031

4. India

5. Academy of Scientific and Innovative Research (AcSIR)

6. Division of Pharmacokinetics and Metabolism

Abstract

The toxic metabolite (E)-2,4-diene-VPA is involved in generation of oxidative stress subsequently contributing in induction of malformations and anomalies and that curcumin affords dose dependent amelioration of the anomalies exerted by VPA.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA13569A

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