Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors-Reference-Cited by-同舟云学术

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Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors

Published:2015 Issue:43 Volume:13 Page:10734-10744
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Cendret V.¹²³⁴⁵,Legigan T.¹²³⁴⁵,Mingot A.¹²³⁴⁵,Thibaudeau S.¹²³⁴⁵,Adachi I.⁶⁷⁸⁹,Forcella M.¹⁰¹¹¹²¹³,Parenti P.¹⁴¹¹¹²¹³,Bertrand J.¹⁵¹⁶¹⁷⁵,Becq F.¹⁵¹⁶¹⁷⁵,Norez C.¹⁵¹⁶¹⁷⁵,Désiré J.¹²³⁴⁵,Kato A.⁶⁷⁸⁹,Blériot Y.¹²³⁴⁵

Affiliation:

1. Université de Poitiers

2. IC2MP

3. UMR CNRS 7285 Equipe“Synthèse Organique”4 rue Michel Brunet

4. 86073 Poitiers cedex 09

5. France

6. Department of Hospital Pharmacy

7. University of Toyama

8. Toyama 930-0194

9. Japan

10. Department of Biotechnology and Biosciences

11. University of Milano-Bicocca

12. 20126 Milano

13. Italy

14. Department of Earth and Environmental Sciences

15. Laboratoire STIM Signalisation et Transports Ioniques Membranaires

16. ERL7368 (0864)- CNRS/Université de Poitiers

17. 86073 Poitiers Cedex 9

Abstract

Synthetic DNJs bearing a thiolated, fluorinated or unsaturated N-substituent exhibit trehalase inhibition or F508del-CFTR correction.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01526J

Reference67 articles.

1. O. R. Martin and P.Compain, Iminosugars: From synthesis to therapeutic applications, Wiley-VCH, Weinheim, 2007

2. Glycosylation inhibitors in biology and medicine

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