Biosynthesis of the RiPP trojan horse nucleotide antibiotic microcin C is directed by the N-formyl of the peptide precursor-Reference-Cited by-同舟云学术

Biosynthesis of the RiPP trojan horse nucleotide antibiotic microcin C is directed by the N-formyl of the peptide precursor

Published:2019 Issue:8 Volume:10 Page:2391-2395
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Dong Shi-Hui¹²³⁴²^ORCID,Kulikovsky Alexey¹²³⁵⁶,Zukher Inna⁵⁶⁷⁸^ORCID,Estrada Paola¹²³,Dubiley Svetlana⁵⁶⁷⁸⁹^ORCID,Severinov Konstantin⁵⁶⁷⁸⁹,Nair Satish K.¹²³⁴²^ORCID

Affiliation:

1. Department of Biochemistry

2. University of Illinois at Urbana-Champaign

3. USA

4. Carl Woese Institute for Genomic Biology

5. Institute of Gene Biology

6. Russian Academy of Science

7. 11934 Moscow

8. Russia

9. Center for Life Sciences

Abstract

The N-formyl moiety of the peptide precursor directs the biosynthesis of the RiPP trojan horse nucleotide antibiotic McC.

Funder

National Institute of Allergy and Infectious Diseases

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC03173H

Reference26 articles.

1. Microcin C: biosynthesis and mechanisms of bacterial resistance

2. Low-molecular-weight post-translationally modified microcins

3. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

4. Structure and organization of plasmid genes required to produce the translation inhibitor microcin C7

5. Chemical Structure and Translation Inhibition Studies of the Antibiotic Microcin C7

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