Acid promoted Ir–P^N complex catalyzed hydrogenation of heavily hindered 3,4-diphenyl-1,2-dihydronaphthalenes: asymmetric synthesis of lasofoxifene tartrate-Reference-Cited by-同舟云学术

Acid promoted Ir–P^N complex catalyzed hydrogenation of heavily hindered 3,4-diphenyl-1,2-dihydronaphthalenes: asymmetric synthesis of lasofoxifene tartrate

Published:2017 Issue:12 Volume:4 Page:2311-2322
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zanotti-Gerosa Antonio¹²³,Gazić Smilović Ivana⁴⁵⁶⁷⁸,Časar Zdenko⁴⁵⁶⁷⁸^ORCID

Affiliation:

1. Johnson Matthey

2. Cambridge CB4 0FP

3. UK

4. Lek Pharmaceuticals

5. d.d.

6. Sandoz Development Center Slovenia

7. SI-1526 Ljubljana

8. Slovenia

Abstract

An asymmetric hydrogenation of minimally functionalized tetrasubstituted cyclic olefins has been developed using an Ir–P^N catalyst and an acid additive enabling the synthesis of lasofoxifene tartrate.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/QO/C7QO00525C

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