Near-infrared absorbing Ru(ii) complexes act as immunoprotective photodynamic therapy (PDT) agents against aggressive melanoma

Author:

Lifshits Liubov M.1234ORCID,Roque III John A.12341ORCID,Konda Prathyusha5678ORCID,Monro Susan910118,Cole Houston D.1234ORCID,von Dohlen David112134,Kim Susy1415164,Deep Gagan1415164,Thummel Randolph P.917184ORCID,Cameron Colin G.1234ORCID,Gujar Shashi567819ORCID,McFarland Sherri A.1234ORCID

Affiliation:

1. Department of Chemistry and Biochemistry

2. The University of Texas at Arlington

3. Arlington

4. USA

5. Department of Microbiology and Immunology

6. Dalhousie University

7. Halifax

8. Canada

9. Department of Chemistry

10. Acadia University

11. Wolfville

12. The University of North Carolina at Greensboro

13. Greensboro

14. Department of Cancer Biology

15. Wake Forest School of Medicine

16. Winston Salem

17. University of Houston

18. Houston

19. Department of Pathology

Abstract

Ru(ii) photosensitizers (PSs) destroy aggressive melanoma cells, triggering an immune response that leads to protection against tumor challenge and mouse survival.

Funder

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Reference142 articles.

1. Photodynamic Therapy: Basic Principles and Clinical Applications , ed. B. W. Henderson and T. J. Dougherty , Dekker , New York , 1992

2. Photodynamic Therapy

3. R. Bonnett , Chemical Aspects of Photodynamic Therapy; Advanced chemistry texts , Gordon and Breach Science Publishers , Amsterdam, The Netherlands , 2000

4. Advances in Photodynamic Therapy: Basic, Translational, and Clinical , ed. M. R. Hamblin and P. Mróz , Artech House engineering in medicine & biology series, Artech House , Boston, Mass , 2008

5. Photophysics and photochemistry of photodynamic therapy: fundamental aspects

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