Direct amide formation in a continuous-flow system mediated by carbon disulfide

Author:

Orsy György12345,Fülöp Ferenc12346,Mándity István M.578910ORCID

Affiliation:

1. Institute of Pharmaceutical Chemistry

2. University of Szeged

3. H-6720 Szeged

4. Hungary

5. MTA TTK Lendület Artificial Transporter Research Group

6. Research Group of Stereochemistry of the Hungarian Academy of Sciences

7. Institute of Materials and Environmental Chemistry

8. Research Center for Natural Sciences

9. Hungarian Academy of Sciences

10. 1117 Budapest

Abstract

We report a direct flow-based synthesis of amides. The developed approach is prominently simple and various aliphatic and aromatic amides were synthetized with excellent yields. The technology is considerably robust and easy scale-up was carried out.

Funder

Magyar Tudományos Akadémia

Ministry for Innovation and Technology

Nemzeti Kutatási, Fejlesztési és Innovaciós Alap

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

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