Potential antiviral activities of camel, bovine, and human lactoperoxidases against hepatitis C virus genotype 4-Reference-Cited by-同舟云学术

Potential antiviral activities of camel, bovine, and human lactoperoxidases against hepatitis C virus genotype 4

Published:2015 Issue:74 Volume:5 Page:60441-60452
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Redwan Elrashdy M.¹²³⁴⁵,Almehdar Hussein A.¹²³⁴⁵,EL-Fakharany Esmail M.⁶⁷⁸⁹¹⁰,Baig Abdul-Wahab K.¹²³⁴⁵,Uversky Vladimir N.¹²³⁴⁵

Affiliation:

1. Department of Biological Science

2. Faculty of Science

3. King Abdulaziz University

4. Jeddah 21589

5. Saudi Arabia

6. Protective and Therapeutic Proteins Laboratory

7. Protein Research Department

8. Genetic Engineering and Biotechnology Research Institute GEBRI

9. City for Scientific Research and Technology Applications

10. Alexandria

Abstract

Lactoperoxidases (LPOs) were assayed against hepatitis C virus (HCV) using PCR. Direct interaction of HCV with LPO neutralized the viral particles and prevented entry into cells. LPOs inhibited virus amplification in infected HepG2 cells with a relative activity of 100%.

Funder

King Abdulaziz University of Saudi Arabia

King Abdulaziz City for Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA11768B

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