Nanotechnological immunoassay for rapid label-free analysis of candidate malaria vaccines

Author:

Brunetti Giulio12345ORCID,Padovani Francesco12345ORCID,De Pastina Annalisa12345ORCID,Rotella Chiara12345,Monahan Amy12345ORCID,Hoffman Stephen L.678,Jongo Said A.9101112,Abdulla Salim9101112,Corradin Giampietro13141516,Pluschke Gerd1718192016ORCID,Daubenberger Claudia2116172219ORCID,Hegner Martin12345ORCID

Affiliation:

1. Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN)

2. School of Physics

3. Trinity College Dublin

4. Dublin

5. Ireland

6. Sanaria Inc.

7. Rockville

8. USA

9. Bagamoyo Research and Training Centre

10. Ifakara Health Institute

11. Bagamoyo

12. Tanzania

13. Biochemistry Department

14. University of Lausanne

15. Epalinges

16. Switzerland

17. Medical Parasitology and Infection Biology Department

18. Molecular Immunology Unit

19. Swiss Tropical and Public Health Institute

20. Basel

21. University of Basel

22. Clinical Immunology Unit

Abstract

Oscillating micro-cantilever array enables immunoassay for single-step label-free analysis of candidate malaria vaccines. Differential read-out reveals epitope-specific timeline of malaria infection in complex serum samples.

Funder

National Institute of Allergy and Infectious Diseases

Kommission für Technologie und Innovation

Science Foundation Ireland

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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