Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling-Reference-Cited by-同舟云学术

Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling

Published:2019 Issue:64 Volume:55 Page:9499-9502
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Robertson Naomi S.¹²³⁴^ORCID,Walsh Stephen J.¹²³⁴^ORCID,Fowler Elaine¹²³⁴^ORCID,Yoshida Masao¹²³⁴⁵,Rowe Sam M.¹²³⁴,Wu Yuteng¹²³⁴,Sore Hannah F.¹²³⁴^ORCID,Parker Jeremy S.⁶⁷⁸⁹⁴^ORCID,Spring David R.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Cambridge

3. Cambridge

4. UK

5. R&D Division, Daiichi Sankyo Co., Ltd.

6. Early Chemical Development

7. Pharmaceutical Sciences

8. IMED Biotech Unit

9. Macclesfield

Abstract

A functionalisable divinyltriazine linker was developed for two-component peptide stapling and macrocyclisation of cysteine residues.

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Medical Research Council

Royal Society

AstraZeneca

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C9CC05042F

Reference35 articles.

1. Reaching for high-hanging fruit in drug discovery at protein–protein interfaces

2. Targeting protein–protein interactions for cancer therapy

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4. Application of Ring-Closing Metathesis to the Synthesis of Rigidified Amino Acids and Peptides

5. Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix

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