A robust photoluminescence screening assay identifies uracil-DNA glycosylase inhibitors against prostate cancer

Author:

Li Guodong1234,Henry Stuart Adam5678,Liu Hao591011,Kang Tian-Shu1234,Nao Sang-Cuo1234,Zhao Yichao12131415,Wu Chun591011,Jin Jianwen12131415,Zhang Jia-Tong1234,Leung Chung-Hang1234ORCID,Wai Hong Chan Philip567812ORCID,Ma Dik-Lung591011ORCID

Affiliation:

1. State Key Laboratory of Quality Research in Chinese Medicine

2. Institute of Chinese Medical Sciences

3. University of Macau

4. Macau

5. Department of Chemistry

6. University of Warwick

7. Coventry CV4 7AL

8. UK

9. Hong Kong Baptist University

10. Kowloon Tong

11. Hong Kong

12. School of Chemistry

13. Monash University

14. Clayton

15. Australia

Abstract

The discovery of UDG inhibitors against prostate cancer by using a robust photoluminescence screening assay that can avoid false negatives arising from the background fluorescence.

Funder

Fundo para o Desenvolvimento das Ciências e da Tecnologia

Health and Medical Research Fund

Universidade de Macau

Hong Kong Baptist University

National Natural Science Foundation of China

Australian Research Council

Natural Science Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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