A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein-Reference-Cited by-同舟云学术

A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein

Published:2020 Issue:18 Volume:11 Page:4773-4778
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhao Yanyan¹²³⁴⁵^ORCID,Tietz Ole¹²³⁴⁵^ORCID,Kuan Wei-Li⁶⁷⁴⁵⁸^ORCID,Haji-Dheere Abdul K.¹²³⁴⁵,Thompson Stephen¹²³⁴⁵^ORCID,Vallin Benjamin⁶⁷⁴⁵⁸,Ronchi Elisabetta¹²³⁴⁵,Tóth Gergely⁹¹⁰¹¹¹²¹³,Klenerman David¹⁴⁴⁵⁸¹⁵,Aigbirhio Franklin I.¹²³⁴⁵^ORCID

Affiliation:

1. Molecular Imaging Chemistry Laboratory

2. Wolfson Brain Imaging Centre

3. Department of Clinical Neurosciences

4. University of Cambridge

5. Cambridge

6. John van Geest Centre for Brain Repair

7. Department of Clinical Neuroscience

8. UK

9. TTK-NAP B – Drug Discovery Research Group – Neurodegenerative Diseases

10. Institute of Organic Chemistry

11. Research Center for Natural Sciences

12. Budapest

13. Hungary

14. Department of Chemistry

15. UK Dementia Research Institute

Abstract

pTP-TFE imaging probe can distinguish soluble tau aggregated proteins from other aggregated proteins enabling earlier detection of neurodegenerative diseases.

Funder

National Institute for Health Research

Engineering and Physical Sciences Research Council

Royal Society

Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/C9SC05620C

Reference41 articles.