Water soluble multiarm-polyethylene glycol–betulinic acid prodrugs: design, synthesis, and in vivo effectiveness-Reference-Cited by-同舟云学术

Water soluble multiarm-polyethylene glycol–betulinic acid prodrugs: design, synthesis, and in vivo effectiveness

Published:2014 Issue:19 Volume:5 Page:5775-5783
ISSN:1759-9954
Container-title:Polym. Chem.
language:en
Short-container-title:Polym. Chem.

Author:

Dai Lin¹²³,Li Dan¹²³,Cheng Jing¹²³,Liu Jing¹²³,Deng Li-Hong¹²³,Wang Lu-Ying¹²³,Lei Jian-Du¹²³,He Jing¹²³

Affiliation:

1. Beijing Key Laboratory of Lignocellulosic Chemistry

2. Beijing Forestry University

3. Beijing 100083, P. R. China

Abstract

Multiarm-polyethylene glycol–betulinic acid prodrugs were prepared by using multiarm-polyethylene glycol linkers and betulinic acid, which exhibited high drug loading capacity, good water solubility, and excellent anticancer activity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2014/PY/C4PY00648H

Reference35 articles.

1. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

2. Research and future trends in the pharmaceutical development of medicinal herbs from Chinese medicine

3. Betulinic Acid and Its Derivatives: A Review on their Biological Properties

4. Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

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