A dual-docking microfluidic cell migration assay (D2-Chip) for testing neutrophil chemotaxis and the memory effect

Author:

Yang Ke12345,Wu Jiandong678910,Xu Guoqing1112910,Xie Dongxue678910,Peretz-Soroka Hagit678910,Santos Susy13910149,Alexander Murray1516910,Zhu Ling12345,Zhang Michael17910,Liu Yong12345,Lin Francis678910ORCID

Affiliation:

1. Institute of Applied Technology

2. Hefei Institutes of Physical Science

3. Chinese Academy of Sciences

4. Hefei

5. P. R. China

6. Department of

7. Physics and Astronomy

8. University of Manitoba

9. Winnipeg

10. Canada

11. Applied Computer Science

12. The University of Winnipeg

13. Victoria General Hospital and River Heights/Fort Garry Community Areas

14. South Winnipeg Integrated Health & Social Services

15. Department of Physics

16. University of Winnipeg

17. Seven Oaks General Hospital

Abstract

We developed a microfluidic device with gradient generation and dual cell alignment function to study neutrophil chemotaxis and chemotactic memory.

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

Oxford University Press (OUP)

Subject

Biochemistry,Biophysics

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