Asymmetric synthesis of β-amino ketones by using cinchona alkaloid-based chiral phase transfer catalysts
Author:
Affiliation:
1. State Key Laboratory Breeding Base of Green Chemistry Synthesis Technology
2. Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province
3. Zhejiang University of Technology
4. Hangzhou 310014
5. China
Abstract
A highly enantioselective nucleophilic addition of ketones to versatile imines catalyzed by chiral PTC has been developed, and the process affords the Mannich reaction products with tertiary stereocenters in good to high yields and excellent enantioselectivities. This protocol is effective for gram scale reaction.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB02484G
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4. Mannich Reaction of Imines and Silyl Enol Ethers Induced by Radical Cation Salts: Synthesis of β-Amino Ketones
5. Efficient Access to Chiral Trisubstituted Aziridines via Catalytic Enantioselective Aza-Darzens Reactions
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