Toxicological risks of Rhizoma paridis saponins in rats involved NF-κB and Nrf2 signaling-Reference-Cited by-同舟云学术

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Toxicological risks of Rhizoma paridis saponins in rats involved NF-κB and Nrf2 signaling

Published:2016 Issue:38 Volume:6 Page:31889-31897
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Li Jing¹²³⁴⁵,Man Shuli¹²³⁴⁵,Qiu Peiyu¹²³⁴⁵,Fan Wei¹²³⁴⁵,Zhang Liming¹²³⁴⁵,Gao Wenyuan⁶⁷⁸⁵⁹

Affiliation:

1. Key Laboratory of Industrial Microbiology

2. Ministry of Education

3. College of Biotechnology

4. Tianjin University of Science & Technology

5. Tianjin

6. Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency

7. School of Pharmaceutical Science and Technology

8. Tianjin University

9. China

Abstract

The aim of the study is to evaluate the safety of long-term use of Rhizoma paridis saponins (RPS).

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA27521K

Reference19 articles.

1. Characterization of steroidal glycosides from the extract of Paris Polyphylla var. Yunnanensis by UPLC/Q-TOF MSE

2. Antitumor pathway of Rhizoma Paridis Saponins based on the metabolic regulatory network alterations in H22 hepatocarcinoma mice

3. Anti-fibrosis and anti-cirrhosis effects of Rhizoma paridis saponins on diethylnitrosamine induced rats

4. Characterization of steroidal saponins in saponin extract from Paris polyphylla by liquid chromatography tandem multi-stage mass spectrometry

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1. Evaluation of the cytotoxicity, oral toxicity, genotoxicity, and mutagenicity of the latex extracted from Himatanthus drasticus (Mart.) Plumel (Apocynaceae);Journal of Ethnopharmacology;2020-05

2. Integrative analysis of proteomic and metabonomics data for identification of pathways related to Rhizoma Paridis-induced hepatotoxicity;Scientific Reports;2020-04-16

3. Similar hepatotoxicity response induced by Rhizoma Paridis in zebrafish larvae, cell and rat;Journal of Ethnopharmacology;2020-03

4. Hepatotoxicity assessment of Rhizoma Paridis in adult zebrafish through proteomes and metabolome;Biomedicine & Pharmacotherapy;2020-01

5. Hepatocellular Toxicity of Paris Saponins I, II, VI and VII on Two Kinds of Hepatocytes-HL-7702 and HepaRG Cells, and the Underlying Mechanisms;Cells;2019-07-09

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