<i>De novo</i> synthesis of dimerization-ready flavan unit <i>via</i> intramolecular Pummerer/Friedel

De novo synthesis of dimerization-ready flavan unit via intramolecular Pummerer/Friedel–Crafts cascade

Published:2022 Issue:37 Volume:20 Page:7419-7423
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Betkekar Vipul V.¹,Suzuki Keisuke¹^ORCID,Ohmori Ken¹^ORCID

Affiliation:

1. Department of Chemistry, Tokyo Institute of Technology, 2-12-1, O-okayama, Meguro-ku, Tokyo 152-8551, Japan

Abstract

Reported herein is a de novo synthesis of a dimerization-ready flavan unit via the Pummerer/Friedel–Crafts cascade, enabling facile access to oligomeric proanthocyanidins.

Funder

Japan Society for the Promotion of Science

Nagase Science Technology Foundation

NOVARTIS Foundation (Japan) for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01416E

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