O2-(6-Oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolates: a new class of nitric oxide donors activatable by GSH/GSTπ with both anti-proliferative and anti-metastatic activities against melanoma-Reference-Cited by-同舟云学术

O2-(6-Oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolates: a new class of nitric oxide donors activatable by GSH/GSTπ with both anti-proliferative and anti-metastatic activities against melanoma

Published:2017 Issue:36 Volume:53 Page:5059-5062
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Bai Chengfeng¹²³⁴,Xue Rongfang¹²³⁴,Wu Jianbing¹²³⁴,Lv Tian¹²³⁴,Luo Xiaojun¹²³⁴,Huang Yun¹²³⁴,Gong Yan¹²³⁴,Zhang Honghua⁵⁶⁷⁸,Zhang Yihua¹²³⁴,Huang Zhangjian¹²³⁴^ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines

2. Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases

3. Jiangsu Key Laboratory of Drug Screening

4. China

5. Foreign Languages Department

6. China Pharmaceutical University

7. Nanjing 210009

8. P. R. China

Abstract

3c, a new nitric oxide donor activatable by GSH/GSTπ, exhibits both anti-proliferative and anti-metastatic activities against melanoma.

Funder

Program for New Century Excellent Talents in University

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C7CC00213K

Reference27 articles.

1. Genetics and epigenetics of cutaneous malignant melanoma: A concert out of tune

2. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

3. CTLA-4 and PD-1/PD-L1 Blockade: New Immunotherapeutic Modalities with Durable Clinical Benefit in Melanoma Patients

4. The yin and yang of nitric oxide in cancer progression

5. Novel therapeutic applications of nitric oxide donors in cancer: Roles in chemo- and immunosensitization to apoptosis and inhibition of metastases

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