Bilayer hydrogel with a protective film and a regenerative hydrogel for effective diabetic wound treatment

Author:

Zhang Jinfeng1ORCID,Li Jing1,Zhang Yang2,Zhao Yueshui134,Shen Jing134,Du Fukuan134,Chen Yu134,Li Mingxing134,Wu Xu134,Chen Meijuan134,Xiao Zhangang134,Deng Shuai134ORCID

Affiliation:

1. Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China

2. Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Southwest Medical University, Luzhou 646000, China

3. Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou 646000, Sichuan, China

4. South Sichuan Institute of Translational Medicine, Luzhou 646000, Sichuan, China

Abstract

A bilayer hydrogel, combining a GelMA-ALG-nZnO protective film and a COL1-PRP regenerative hydrogel, offers protection against bacterial infection and promotes wound healing function, addressing the complexities of diabetic foot treatment.

Funder

Department of Science and Technology of Sichuan Province

Luzhou Science and Technology Bureau

Publisher

Royal Society of Chemistry (RSC)

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