Desymmetric hydrolysis of prochiral imide for <i>S</i>-pregabalin synthesis by rationally designed <scp>d</scp>-hydantoinase-Reference-Cited by-同舟云学术

Desymmetric hydrolysis of prochiral imide for S-pregabalin synthesis by rationally designed d-hydantoinase

Published:2022 Issue:12 Volume:24 Page:4748-4753
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Liu Feixia¹,Ren Jie²,Guo Lu³,Liu Yang¹⁴,Li De-Feng³^ORCID,Yu Bo¹^ORCID

Affiliation:

1. CAS Key Laboratory of Microbial Physiological & Metabolic Engineering, State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

2. State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100029, China

3. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China

4. University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

A one-step enzymatic desymmetrization process was developed to produce the direct chiral precursor for S-pregabalin synthesis with high yield and high eep value.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/GC/D2GC00728B

Reference29 articles.

1. Pregabalin: A New Neuromodulator with Broad Therapeutic Indications

2. From Basic Science to Blockbuster Drug: The Discovery of Lyrica

3. System L: heteromeric exchangers of large, neutral amino acids involved in directional transport

4. A Comparison of the Pharmacokinetics and Pharmacodynamics of Pregabalin and Gabapentin

5. Enantioselective synthesis of PD144723: a potent stereospecific anticonvulsant.

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