A self-assembled nanophotosensitizer targets lysosomes and induces lysosomal membrane permeabilization to enhance photodynamic therapy-Reference-Cited by-同舟云学术

A self-assembled nanophotosensitizer targets lysosomes and induces lysosomal membrane permeabilization to enhance photodynamic therapy

Published:2023 Issue:19 Volume:14 Page:5106-5115
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Li Youyou¹,Han Wenbo¹,Gong Deyan²,Luo Taokun¹,Fan Yingjie¹,Mao Jianming¹,Qin Wenwu²^ORCID,Lin Wenbin¹³^ORCID

Affiliation:

1. Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA

2. Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China

3. Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL 60637, USA

Abstract

Self-assembly of amphiphilic photosensitizer BDQ into BDQ-NP enables stable incorporation of BDQ into lysosome membranes to cause continuous lysosomal membrane permeabilization for highly effective photodynamic therapy.

Funder

National Cancer Institute

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC00455D

Reference52 articles.

1. Nanoparticles in Photodynamic Therapy

2. Clinical development and potential of photothermal and photodynamic therapies for cancer