A successful search for new, efficient, and silver-free manufacturing processes for key platinum(ii) intermediates applied in antibody–drug conjugate (ADC) production
Author:
Affiliation:
1. LinXis BV
2. De Boelelaan 1085c
3. The Netherlands
4. ChemConnection BV/Ardena Oss
5. Oss, 5349 AB
6. Department of Radiology and Nuclear Medicine
7. Amsterdam UMC
8. Location VU Medical Center
9. Amsterdam
Abstract
A silver-free amination procedure was developed to obtain an important class of Pt(II) complexes as direct precursors for antibody-drug conjugates.
Publisher
Royal Society of Chemistry (RSC)
Subject
Pollution,Environmental Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/GC/C9GC03130H
Reference29 articles.
1. The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma
2. Ado-trastuzumab Emtansine (T-DM1): An Antibody–Drug Conjugate (ADC) for HER2-Positive Breast Cancer
3. Inotuzumab Ozogamicin: First Global Approval
4. Recent Developments in ADC Technology: Preclinical Studies Signal Future Clinical Trends
5. An FDA oncology analysis of antibody-drug conjugates
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