Localized and regulated peptide pigment formation inside liquid droplets through confined enzymatic oxidation

Author:

Barriales Kenny123,Kassem Salma1,Sementa Deborah1,Vidal Ceballos Alfredo134,Wang Tong1ORCID,Khandaker Shadman1,Abzalimov Rinat R.1,Jain Ankit3564,Elbaum-Garfinkle Shana134,Ulijn Rein V.1234ORCID

Affiliation:

1. Advanced Science Research Center (ASRC) at the Graduate Center, City University of New York (CUNY), 85 St Nicholas Terrace, New York, New York 10031, USA

2. Department of Chemistry, Hunter College, City University of New York, 695 Park Avenue, New York, New York 10065, USA

3. Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, New York 10016, USA

4. Ph.D. Program in Biochemistry, The Graduate Center of the City University of New York, New York, New York, 10016, USA

5. Department of Chemistry and Biochemistry, Brooklyn College, City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, USA

6. Brooklyn College Cancer Center, Brooklyn College, The City University of New York, 2900 Beford Ave, Brooklyn, NY 11210, USA

Abstract

We demonstrate multi-component liquid peptide droplets that upon enzymatic oxidation, give rise to the formation of soluble polyphenolic pigments as simple mimics of the biological pigment, melanin.

Funder

Office of Naval Research

Air Force Office of Scientific Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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