Arsenic trioxide-loaded nanoparticles enhance the chemosensitivity of gemcitabine in pancreatic cancer <i>via</i> the reversal of pancreatic stellate cell desmoplasia by targeting the AP4/galectin-1 pathway-Reference-Cited by-同舟云学术

Arsenic trioxide-loaded nanoparticles enhance the chemosensitivity of gemcitabine in pancreatic cancer via the reversal of pancreatic stellate cell desmoplasia by targeting the AP4/galectin-1 pathway

Published:2022 Issue:20 Volume:10 Page:5989-6002
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Zhao Yue¹²^ORCID,Yao Hanming¹²,Yang Kege¹²,Han Shiji¹²,Chen Shangxiang¹²,Li Yaqing¹²,Chen Shaojie¹²,Huang Kaihong¹²,Lian Guoda¹²,Li Jiajia³¹²

Affiliation:

1. Department of Gastroenterology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China

2. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China

3. Department of Nephrology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, Guangdong, China

Abstract

ScAb-ATO-NPs targets PSCs to increase the delivery efficiency of ATO to PSCs. ATO inhibits the activation of PSCs via PI3K/AKT/AP4/galectin-1 pathway and decreases the synthesis of ECM in PDAC, which enhances the chemotherapy in PDAC.

Funder

Medical Science and Technology Foundation of Guangdong Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D2BM01039A

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