Design and synthesis of water-soluble grifolin prodrugs for DNA methyltransferase 1 (DNMT1) down-regulation-Reference-Cited by-同舟云学术

Design and synthesis of water-soluble grifolin prodrugs for DNA methyltransferase 1 (DNMT1) down-regulation

Published:2021 Issue:61 Volume:11 Page:38907-38914
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Wang Liguo¹^ORCID,Wu Yue¹,Li Zhenzhen²³⁴⁵,Lan Tianlong¹^ORCID,Zhao Xu²³⁴⁵,Lv Wenxing¹,Shi Feng²³⁴⁵,Luo Xiangjian²³⁴⁵,Rao Yu¹^ORCID,Cao Ya²³⁴⁵

Affiliation:

1. Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China

2. Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Central South University, Changsha 410078, China

3. Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, 410078, China

4. Molecular Imaging Research Center of Central South University, Changsha, China

5. National Joint Engineering Research Center for Genetic Diagnostics of Infectious Diseases and Cancer, Changsha 410078, China

Abstract

In this work, a series of prodrugs of grifolin with much improved solubility and stability were designed and synthesis, which potently downregulated DNMT1 and inhibited tumor proliferation in vitro and in vivo.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Natural Science Foundation of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA06648J

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