Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1–P2 ligands-Reference-Cited by-同舟云学术

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Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1–P2 ligands

Published:2014 Issue:35 Volume:12 Page:6842-6854
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ghosh Arun K.¹²³,Schiltz Gary E.¹²³,Rusere Linah N.¹²³,Osswald Heather L.¹²³,Walters D. Eric⁴⁵⁶,Amano Masayuki⁷⁸⁹,Mitsuya Hiroaki⁷⁸⁹¹⁰¹¹

Affiliation:

1. Departments of Chemistry and Medicinal Chemistry

2. Purdue University

3. West Lafayette, USA

4. Department of Pharmaceutical Sciences

5. Rosalind Franklin University of Medicine and Science

6. North Chicago, USA

7. Kumamoto University School of Medicine

8. Department of Hematology and Infectious diseases

9. Kumamoto 860-8556, Japan

10. Experimental Retrovirology Section

11. HIV and AIDS Malignancy Branch

Abstract

A series of potent macrocyclic HIV-1 protease inhibitors have been designed and synthesized.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00738G

Reference36 articles.

1. Demonstration of Sustained Drug-Resistant Human Immunodeficiency Virus Type 1 Lineages Circulating among Treatment-Naïve Individuals

2. HAART in treatment-experienced patients in the 21st century: the audacity of hope

3. Emergence of Drug Resistance in HIV Type 1–Infected Patients after Receipt of First‐Line Highly Active Antiretroviral Therapy: A Systematic Review of Clinical Trials

4. Public Health Implications of Antiretroviral Therapy and HIV Drug Resistance

5. Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV

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1. The Missing Link(er): A Roadmap to Macrocyclization in Drug Discovery;Journal of Medicinal Chemistry;2024-08-22

2. Unveiling Novel HIV-1 Protease Inhibitors through an Integrated Analysis of 3D-QSAR, Molecular Docking, and Binding Free Energy;Letters in Drug Design & Discovery;2024-06-03

3. Research Progress in HIV and Mycobacterium tuberculosis Inhibitors Containing Sulfonamide Moiety;Journal of Chemistry;2023-12-07

4. Beyond darunavir: recent development of next generation HIV-1 protease inhibitors to combat drug resistance;Chemical Communications;2022

5. Studies directed toward the synthesis of hedycoropyrans: total synthesis of des-hydroxy (−)-hedycoropyran B (ent-rhoiptelol B);Organic & Biomolecular Chemistry;2022

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