One-pot synthesis of tetrahydro-pyrrolobenzodiazepines and tetrahydro-pyrrolobenzodiazepinones through sequential 1,3-dipolar cycloaddition/N-alkylation (N-acylation)/Staudinger/aza-Wittig reactions-Reference-Cited by-同舟云学术

One-pot synthesis of tetrahydro-pyrrolobenzodiazepines and tetrahydro-pyrrolobenzodiazepinones through sequential 1,3-dipolar cycloaddition/N-alkylation (N-acylation)/Staudinger/aza-Wittig reactions

Published:2019 Issue:16 Volume:21 Page:4489-4494
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Ma Xiaoming¹²³⁴^ORCID,Zhang Xiaofeng⁵⁶⁷⁸^ORCID,Awad John Mark⁵⁶⁷⁸,Xie Guoshu⁵⁶⁷⁸,Qiu Weiqi⁵⁶⁷⁸,Zhang Wei⁵⁶⁷⁸^ORCID

Affiliation:

1. School of Pharmaceutical Engineering and Life Science

2. Changzhou University

3. Jiangsu 213164

4. P. R. China

5. Department of Chemistry

6. University of Massachusetts Boston

7. Boston

8. USA

Abstract

A new diastereoselective synthesis of benzodiazepines and diazepinones is developed. This one-pot and three-step synthesis of four components gave two different heterocyclic scaffolds. Green chemistry metrics analysis of the reaction processes provided favorable results.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/GC/C9GC01642B

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3. Bicyclic Diazepines: Diazepines with an Additional Ring , in The Chemistry of Heterocyclic Compounds , ed. R. I. Fryer , Wiley , New York , 2008

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